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101 Top San Francisco Biotechnology Companies and Startups of 2021

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This article showcases our top picks for the best San Francisco based Biotechnology companies. These startups and companies are taking a variety of approaches to innovating the Biotechnology industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

Top San Francisco Biotechnology Startups

Data sourced from Crunchbase and SemRush.

Benchling

Benchling

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Benchling is a cloud-based software platform for biology researchers and research and development organizations.

Twist Bioscience

Twist Bioscience

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Twist Bioscience is a synthetic DNA production for specialty chemical compounds and drug development.

Twist Bioscience

Invitae

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Invitae is a medical genetics company that bring comprehensive genetic information into mainstream medicine to improve healthcare.

Twist Bioscience

Engine Biosciences

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Engine Biosciences is a biotech company that applies machine learning to genomics for drug discovery.

Twist Bioscience

Vir Biotechnology

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Vir Biotechnology is a clinical-stage immunology company developing therapeutic products to treat and prevent serious infectious diseases.

Twist Bioscience

Circle Pharma

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Circle Pharma is a provider of a macrocycle development platform intended to provide macrocyclic peptides.

Twist Bioscience

Aizon

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Aizon is a cloud-based SaaS platform that helps optimize industrial processes in biotech and pharma.

Twist Bioscience

PicnicHealth

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PicnicHealth helps patients easily access their medical records and gives them the opportunity to contribute data to medical research.

Twist Bioscience

Mammoth Biosciences

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Mammoth Biosciences develops novel CRISPR applications for disease detection, research, agriculture, biodefense, and more.

Twist Bioscience

Bluestar Genomics

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Bluestar Genomics delivers epigenomic and big data approaches to reinvent non-invasive molecular diagnostic testing.

Twist Bioscience

Vineti

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Vineti is a commercial cloud-based platform that expands patient access to life-saving cells and gene therapies.

Twist Bioscience

Alector

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Alector is combining state-of-the-art antibody technology and recent discoveries in neuroimmunology and human genetics to develop novel.

Twist Bioscience

FibroGen

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FibroGen, a research-based biotech firm, uses its expertise CTGF and HIF biology to discover, develop, and commercialize novel therapeutics.

Twist Bioscience

Denali Therapeutics

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Denali Therapeutics is a biotechnology company.

Twist Bioscience

Mission Bio

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Mission Bio develops only single-cell multi-omics platform integrating genotype and phenotype for cancer research and biomarker development.

Twist Bioscience

Pendulum Therapeutics

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Pendulum Therapeutics is a biotechnology company improving health through products targeting the microbiome.

Twist Bioscience

Codiak Biosciences

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Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics.

Twist Bioscience

Verge Genomics

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Verge Genomics uses machine learning and human genomics to accelerate drug discovery

Twist Bioscience

Vaxart

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Vaxart is a biotechnology company that develops vaccine technology for the treatment of infectious diseases.

Twist Bioscience

Better Therapeutics

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Better develops prescription software for treating cardiometabolic diseases.

Twist Bioscience

Brightseed

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Brightseed features artificial intelligence that reveals powerful compounds hidden in nature.

Twist Bioscience

Chronicled

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Chronicled builds trust and automation in the life science industry, powered by blockchain

Twist Bioscience

Nurix Therapeutics

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Nurix develops small molecule inhibitors for the treatment of proliferative and degenerative diseases.

Twist Bioscience

Brii Biosciences

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Brii Biosciences is a biotechnology company that commits to bring innovative medicines to China as a way to improve public health.

Twist Bioscience

Miroculus

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Miroculus is a hands off sample-to-answer solution for molecular testing.

Twist Bioscience

BlackThorn Therapeutics

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BlackThorn Therapeutics is a clinical-stage neurobehavioral health company pioneering the next generation of artificial intelligence.

Twist Bioscience

Wildtype

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Wildtype is an agtech platform that aims to create clean fish and meat.

Twist Bioscience

Nebula Genomics

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Nebula Genomics leverages blockchain technology to eliminate middlemen and empower people to own their personal genomic data.

Twist Bioscience

Global Blood Therapeutics

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GBT is a clinical-stage biopharmaceutical company developing its lead product candidate, voxelotor, as a therapy for sickle cell disease.

Twist Bioscience

Darmiyan

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Darmiyan is developing an AI-powered software platform for early detection, monitoring, and stratification of Alzheimer’s disease

Twist Bioscience

Aligos Therapeutics

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Aligos Therapeutics is discovering and developing new classes of molecules that interact directly with disease-causing modalities.

Twist Bioscience

Profusa

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PROFUSA is a medical devices company creating tissue-integrated sensors for chronic disease management and healthy living.

Twist Bioscience

Ossium Health

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Ossium Health is building the world’s first bone marrow bank to treat blood cancers

Twist Bioscience

Olema Oncology

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Olema Oncology is a preclinical biotechnology company that develops new drugs for the treatment and prevention of breast cancer.

Twist Bioscience

Spruce Biosciences

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Spruce Biosciences is a biopharmaceutical company that focuses on developing therapies for rare diseases that targets endocrine system.

Twist Bioscience

ALX Oncology

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ALX Oncology is a preclinical stage biotechnology company developing innovative immuno-oncology therapies for cancer.

Twist Bioscience

Audentes Therapeutics

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Audentes is a biotechnology company that employs gene therapy technology to develop treatments for people with rare muscle diseases.

Twist Bioscience

Five Prime Therapeutics

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FivePrime is a clinical-stage biotechnology company that develops treatments for cancers.

Twist Bioscience

Artemys Foods

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Artemys Foods works on the next generation of meat alternatives by cultivating meat, instead of harvesting meat from animals.

Twist Bioscience

Frontier Medicines

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Frontier Medicines is a developer of a chemoproteomics platform intended to further accelerate the path to drug discovery.

Twist Bioscience

Feel

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Feel provides continuous monitoring and real-time personalized interventions for individuals that suffer from anxiety and depression.

Twist Bioscience

Second Genome

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Second Genome offers a pipeline of microbiome modulators that impact infection, immunity and metabolic diseases.

Twist Bioscience

Tenaya Therapeutics

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Tenaya Therapeutics is a developer of novel therapies designed to offer treatment for heart disease.

Twist Bioscience

Asher Bio

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Asher Bio is a biotechnology company that specializes in the fields of therapeutics builds better immunotherapy for cancer.

Twist Bioscience

Soteria Biotherapeutics

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Soteria is a biotechnology company that develops immunotherapies to treat cancer patients

Twist Bioscience

89bio

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89Bio is a biopharmaceutical company building a pipeline of biologic and small molecule treatments for liver and metabolic disorders.

Twist Bioscience

Turnstone Biologics

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Turnstone Biologics is a privately-held clinical stage biotech company.

Twist Bioscience

Attralus

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Attralus is a biopharmaceutical company focusing on creating transformative medicines to improve the lives of patients.

Twist Bioscience

Pheronym

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Pheronym is creating an all-natural highly effective insect control for agriculture.

Twist Bioscience

Headlands Research

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Headlands Research is a globally integrated clinical trial site organization with a mission to improve the clinical trials process.

Twist Bioscience

Celevity

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Celevity is a seed-stage company that develops drugs to help dogs live longer, healthier lives.

Twist Bioscience

Prellis Biologics

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Prellis Biologics is building human tissues for drug development, and ultimately, developing human organs for transplantation.

Twist Bioscience

Biome Makers

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Biome Makers is specialized in microbiome understanding to provide comprehensive analysis for agricultural and industrial processes.

Twist Bioscience

Mantra Bio

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Mantra Bio is the creator of REVEAL, an exosome engineering platform combining computational biology and lab automation.

Twist Bioscience

Phylagen

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Phylagen is digitizing the global microbiome to create a more transparent world

Twist Bioscience

Enveda Biosciences

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Enveda Biosciences is a biotechnology company building new medicines from plants.

Twist Bioscience

Orchid

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Orchid is a reproductive technology startup that is capable of detecting rare genetic disorders.

Twist Bioscience

Invuity

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Invuity develops illumination and visualization products for minimally invasive surgical field applications.

Twist Bioscience

LevitasBio

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LevitasBio is is advancing science and human health by providing researchers with a new and powerful method of cellular analysis.

Twist Bioscience

Mekonos Inc.

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Building the Future of Cell Therapies on a Chip

Twist Bioscience

ZBiotics

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ZBiotics is a synthetic biology company that bioengineers probiotic bacteria for nutraceutical and other applications.

Twist Bioscience

System1 Biosciences

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System1 Biosciences is a neurotherapeutics company.

Twist Bioscience

Cofactor Genomics

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Using Predictive Immune Modeling and RNA, Cofactor Genomics builds multidimensional models of disease to deliver true precision medicine.

Twist Bioscience

Neurona Therapeutics

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Neurona Therapeutics is a provider of cell-based medicines dealing with neurological disorders.

Twist Bioscience

goBalto

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GoBalto is a software platform that develops cloud-based solutions for drug trial sponsors and clinical research organizations.

Twist Bioscience

University of California, San Francisco

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Director of the Lab for Advanced Cytometry (LAC) and the Sony Biotechnology Center at UCSF in the Department of Laboratory Medicine

Twist Bioscience

Shasqi

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Shasqi develops cancer treatment intended to use bio-orthogonal chemistry for localized drug delivery.

Twist Bioscience

Amgen Ventures

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Amgen Ventures is a California-based investment firm focused on early- and late-stage biotechnology companies.

Twist Bioscience

PipelineRx

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PipelineRx is a clinical telepharmacy services company that offers clinical telepharmacist teams to its hospital clients.

Twist Bioscience

Tempest Therapeutics

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Tempest Therapeutics is a biotechnology company that focuses on small molecule therapeutics that modulate anti-tumor pathways.

Twist Bioscience

Endogena Therapeutics

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Endogena Therapeutics is a biotech company that develops endogenous regenerative medicines to repair and regenerate tissues and organs.

Twist Bioscience

CASPR Biotech

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CASPR Biotech develops a CRISPR-based platform for molecular detection.

Twist Bioscience

PostEra

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Medicinal Chemistry as a Service powered by Machine Learning

Twist Bioscience

Channel Medsystems

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Channel Medystems is a clinical-stage medical technology engaged in the development of proprietary cryo-ablation delivery technologies.

Twist Bioscience

AcertaPharma

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Acerta Pharma provides drug discovery and development services for oncology and autoimmune diseases.

Twist Bioscience

Perlara

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Perlara, PBC is precision drug discovery that leaves no mutation behind.

Twist Bioscience

Meissa Vaccines

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Meissa Vaccines is a pharmaceutical company focused on advancement of unmet vaccines against viruses that cause serious human diseases.

Twist Bioscience

BioQ Pharma

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BioQ Pharma is a late stage specialty pharmaceutical company focused on developing.

Twist Bioscience

Zephyr Health

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Zephyr Health operates as an insights-as-a-service solution built specifically for life sciences companies.

Twist Bioscience

Correlia Biosystems

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Rapid Diagnostics and Proteomics

Twist Bioscience

Coral Genomics

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harnessing diverse human biology to improve drug effectiveness and prior auth

Twist Bioscience

AmbAgon Therapeutics

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AmbAgon Therapeutics is a developer of cancer molecule therapeutics.

Twist Bioscience

Siolta Therapeutics

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Siolta Therapeutics is a developer of human microbiome therapeutics intended to prevent and treat inflammatory diseases.

Twist Bioscience

Aeovian Pharmaceuticals

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Aeovian Pharmaceuticals aims to discover, develop, and commercialize therapeutics for the treatment of rare and age-related diseases.

Twist Bioscience

Actym

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Actym is a biotechnology company that focuses on developing an immuno-oncology platform.

Twist Bioscience

Cleave Therapeutics

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Cleave Therapeutics is focused on protein homeostasis and stress pathways in cancer and neurodegeneration.

Twist Bioscience

Ligandal

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Ligandal is creating cell-specific delivery systems for gene editing tools such as CRISPR using automation and peptide-based nanoparticles.

Twist Bioscience

Slope.io

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Slope.io is a provider of a healthcare software designed to offer an easy way to prevent inventory outages.

Twist Bioscience

Carmot Therapeutics

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Carmot Therapeutics develops drugs to treat inflammatory, metabolic and neurological diseases.

Twist Bioscience

Fountain Therapeutics

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Fountain Therapeutics is discovering and developing treatments for aging-associated diseases.

Twist Bioscience

Xcell Biosciences

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Next generation development and manufacturing platform for enhanced cell therapy performance

Twist Bioscience

Indee Labs

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Indee Labs is unlocking gene-modified cell therapy for the masses with scalable hardware for gene delivery.

Twist Bioscience

Renewal Mill

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Renewal Mill is a next generation ingredients company that upcycles byproducts from food manufacturing into high-quality ingredients.

Twist Bioscience

McKesson

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McKesson distributes medical supplies, information technology, and care management products and services.

Twist Bioscience

Scribe Biosciences

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Flexible tools for single cell analysis

Twist Bioscience

Huue

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Tinctorium is a provider of indigo dyeing solutions intended to reduce chemical usage in the denim supply chain.

Twist Bioscience

Kuleana

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Kuleana creates plant-based alternatives for people’s seafood favorites.

Twist Bioscience

GENETICA® US

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Genetica® – Leading Gene Decoding In Asia

Twist Bioscience

Naked Biome

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Naked Biome is a microbiome-based therapeutics company, launching advanced therapies to treat and prevent skin disease.

Twist Bioscience

Virus Geeks Inc.

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SaaS, Mobile App, BioHealth, Information Technology

Twist Bioscience

Ionetix

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Ionetix is a pioneering end-to-end radiopharmaceutical provider for cardiac PET imaging.

Written by Mark Smith

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