San Francisco is a global hub for AI innovation, hosting hundreds of cutting-edge AI startups. In 2025, the city continues to lead in artificial intelligence, offering groundbreaking solutions across healthcare, robotics, software, and enterprise AI applications. This article explores the top 10 AI startups in San Francisco 2025, their revenue, investments, 10 key features, and emerging job roles in the field of AI startups.

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Top 10 AI Startups in San Francisco 2025

1. OpenAI – Visit Website

1. Developer of GPT-4, DALL·E, and ChatGPT.
2. Revenue estimated in billions.
3. Major funding partner: Microsoft.
4. Focus on AGI safety and alignment.
5. Provides API access for developers.
6. Partnerships with top tech firms.
7. Extensive research publications.
8. Open-source AI initiatives.
9. Global collaborations on AI research.
10. Continuous model improvements for enterprise and consumer applications.
    Job Roles: AI Research Scientist, ML Engineer, Prompt Engineer, AI Policy Specialist

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2. Anthropic – Visit Website

1. Focus on AI safety and interpretability.
2. Created Claude language models.
3. Revenue not publicly disclosed.
4. Funding: $580M from investors including Sam Bankman-Fried.
5. Research-driven AI solutions.
6. Collaborates with academic institutions.
7. Ethical AI development practices.
8. Scalable AI solutions for enterprises.
9. Active involvement in AI policy discussions.
10. Diverse team with deep AI expertise.
    Job Roles: AI Safety Researcher, Machine Learning Engineer, Product Manager

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3. Replit – Visit Website

1. AI-powered code development platform.
2. Supports multiple programming languages.
3. Revenue: $150M annualized.
4. Funding: $250M Series D, $3B valuation.
5. Real-time collaboration tools.
6. AI assistants for coding.
7. Cloud-based development environment.
8. Template library and marketplace.
9. Educational resources for learners.
10. Strong developer community engagement.
    Job Roles: AI Developer, Frontend/Backend Engineer, Community Manager

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4. Figure – Visit Website

1. Develops humanoid robots for commercial and household use.
2. AI-driven robotics platform “Helix”.
3. Revenue not disclosed.
4. Funding: $1.1B Series C; valuation $39B.
5. BotQ advanced manufacturing technology.
6. Partnerships with major tech firms.
7. Focus on labor shortage solutions.
8. Data collection for continuous improvements.
9. Scalable robotics solutions.
10. Ethical AI deployment strategies.
    Job Roles: Robotics Engineer, AI Researcher, Product Designer

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5. Scale AI – Visit Website

1. Data labeling services for AI models.
2. Scalable contractor-based workforce.
3. Revenue not disclosed.
4. Funding: $100M Series D; valuation $7.3B.
5. Partnerships with tech giants.
6. Quality control and AI-driven QA.
7. Global workforce management.
8. Compliance with labor standards.
9. Flexible work opportunities.
10. Continuous platform enhancements for AI models.
    Job Roles: Data Scientist, AI Annotator, ML Engineer

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6. Runway – Visit Website

1. AI-powered video editing platform.
2. Real-time collaboration features.
3. Cloud-based editing environment.
4. Advanced visual effects capabilities.
5. Extensive template library.
6. AI-driven content recommendations.
7. Cross-platform accessibility.
8. User-friendly interface.
9. Active community support.
10. Integration with popular media platforms.
    Job Roles: Video AI Engineer, UI/UX Designer, Media Integration Specialist

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7. Fireflies – Visit Website

1. AI meeting assistant for transcription and analysis.
2. Integrates with Zoom, Google Meet, and Teams.
3. Real-time transcription and summarization.
4. Action item extraction.
5. Searchable meeting archives.
6. Voice command support.
7. Multi-language transcription support.
8. Customizable templates for teams.
9. Analytics dashboards for meeting data.
10. Collaboration features for remote teams.
    Job Roles: NLP Engineer, Product Manager, Customer Success Specialist

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8. People.ai – Visit Website

1. AI-driven revenue intelligence platform.
2. Automates CRM data entry.
3. Provides actionable sales insights.
4. Predictive analytics for pipeline management.
5. Customizable dashboards.
6. Team performance tracking.
7. Lead scoring algorithms.
8. Integrates with Salesforce, HubSpot, and more.
9. Advanced reporting capabilities.
10. Improves overall sales productivity with AI.
    Job Roles: Data Scientist, Sales Engineer, Product Analyst

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9. Kite – Visit Website

1. AI-powered code completion tool.
2. Supports multiple programming languages.
3. Real-time code suggestions in IDEs.
4. Offline functionality.
5. Contextual recommendations based on coding patterns.
6. Learning from user coding behavior.
7. Templates for repeated code structures.
8. Extensive documentation for developers.
9. Active developer community.
10. Reduces coding time and improves efficiency.
    Job Roles: AI Software Engineer, Developer Advocate, ML Researcher

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10. World Labs – Visit Website

1. Focus on AI research and advanced model development.
2. Founded in 2024 by Fei-Fei Li.
3. Revenue not disclosed.
4. Funding: $291.5M led by Fei-Fei Li.
5. Ethical AI practices.
6. Collaborations with top academic institutions.
7. Open AI research publications.
8. Scalable AI solutions for multiple industries.
9. Global impact through AI research collaborations.
10. Active participation in AI policy and development discussions.
    Job Roles: AI Research Scientist, Project Lead, AI Policy Advisor

San Francisco remains the leading hub for AI startups in 2025, offering opportunities for innovation, investment, and career growth. From OpenAI to World Labs, these top 10 AI startups are driving the future of artificial intelligence across industries.

If you’re passionate about AI and want to stay updated on the latest startup trends, follow BestStartup.us for more updates on AI startups in the U.S.