101 Top Minnesota Biotechnology Companies and Startups of 2021

July 6, 2021
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This article showcases our top picks for the best Minnesota based Biotechnology companies. These startups and companies are taking a variety of approaches to innovating the Biotechnology industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

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Top Minnesota Biotechnology Startups

Data sourced from Crunchbase and SemRush.

Medtronic

Medtronic

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Medtronic develops and manufactures medical device technologies and therapies to treat chronic diseases worldwide.

Mayo Clinic

Mayo Clinic

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MayoClinic is a nonprofit medical practice and medical research group focused on integrated health care, education, and research.

Mayo Clinic

Miromatrix Medical

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Miromatrix Medical is engaged in the development of fully biological human organs and organ-derived biological products.

Mayo Clinic

CVRx

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CVRx is a medical device company developing implantable technology for the treatment of high blood pressure.

Mayo Clinic

Inspire Medical Systems

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Inspire Medical Systems develops implantable therapeutic devices for the treatment of obstructive sleep apnea.

Mayo Clinic

Vireo Health

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Vireo Health is a physician-led company dedicated to providing patients with best-in-class cannabis-based products and high quality care

Mayo Clinic

Relievant Medsystems

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Relievant provides patients with low risk therapy that affords the ability to alleviate their back pain.

Mayo Clinic

Nuvaira

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Nuvaira is a new alternative COPD treatment option that specializes in developing devices for treating lung diseases.

Mayo Clinic

Panbela Therapeutics

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Panbela Therapeutics develops small molecule pharmaceuticals for the oncology and acute care markets.

Mayo Clinic

Calyxt

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Calyxt is an Agbiotech company focused on developing crops with healthier characteristics

Mayo Clinic

Recombinetics

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Recombinetics targets biomedical and regenerative medicine, opening vast new opportunities to improve and extend human life.

Mayo Clinic

ANI Pharmaceuticals

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ANI Pharmaceuticals manufactures oral solid dose products, as well as liquids and topicals.

Mayo Clinic

EnteroMedics

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EnteroMedics® Inc. (NASDAQ: ETRM) is the developer of in-class weight loss treatments for obesity and obesity related risk factors.

Mayo Clinic

Conventus Orthopaedics

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Conventus Orthopaedics is a provider of a range of orthopedic and sports medicine services.

Mayo Clinic

StemoniX

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StemoniX is a biotechnology company that focuses on stem cell technologies to meet the demands of drug discovery and personalized medicine.

Mayo Clinic

NeoChord

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NeoChord is a medical device company that develops devices that allow mitral valve repair to be performed on a beating heart.

Mayo Clinic

BioAmber

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BioAmber is a sustainable chemicals firm combining biotechnology and chemical catalysis to convert renewable feedstock into chemicals.

Mayo Clinic

Ativa Medical

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Ativa Medical is working to make diagnostic test results available in moments, rather than hours and days.

Mayo Clinic

Rebiotix

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Rebiotix is a development-stage biotechnology company focusing on the treatment of GI diseases by developing human microbiome.

Mayo Clinic

Biothera

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Biothera is a biotechnology company developing natural gluco polysaccharides that engage and direct natural innate immune systems.

Mayo Clinic

Humanetics Corporation

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clinical stage pharmaceutical company.

Mayo Clinic

NxThera

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NxThera develops medical technologies to treat a variety of endourology conditions, including BPH.

Mayo Clinic

Cardiovascular Systems

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Cardiovascular Systems develops and markets medical devices for the treatment of cardiovascular disease.

Mayo Clinic

Entellus Medical

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Entellus Medical develops technology-based treatment solutions for ENT physicians, their patients and payers.

Mayo Clinic

CHF Solutions

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CHF Solutions is a medical device company that focuses on innovative cardiac assist therapy to treat patients.

Mayo Clinic

Silk Technologies

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SILKTECH focuses on innovating and developing silk-derived protein (SDP) products for ophthalmic applications

Mayo Clinic

Celcuity

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Celcuity transform care for patients with cancer or autoimmune disease.

Mayo Clinic

OneOme

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OneOme is a collaborative concern between the business builder .

Mayo Clinic

Neuroone Medical Technologies

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NeuroOne is a medical technology company focused on improving surgical care for patients suffering from neurological disorders.

Mayo Clinic

Osprey Medical

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Osprey Medical develops and commercializes its propriety CINCOR™ System designed for the prevention of contrast induced mephropathy.

Mayo Clinic

Rotation Medical

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Rotation Medical develops treatments for rotator cuff disease by reversing disease progression and restoring long-term shoulder function.

Mayo Clinic

Imbio

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Imbio develops medical imaging software solutions that save lives and reduce costs.

Mayo Clinic

Metavention

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Metavention develops medical devices to help with interventional therapies for Type 2 diabetes.

Mayo Clinic

Marker Therapeutics

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Marker Therapeutics is a clinical-stage developer of a transformative, non-genetically engineered, multi-antigen T cell therapy platform.

Mayo Clinic

Torax Medical

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Torax Medical develops an implantable device for the treatment of gastroesophageal reflux disease.

Mayo Clinic

Vyriad

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Vyriad is a clinical stage biopharmaceutical company.

Mayo Clinic

DiaMedica

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DiaMedica is a biopharmaceutical company focused on developing innovative treatments for stroke.

Mayo Clinic

Cogentix Medical

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Cogentix Medical products have increased treatment efficiency and lowered patient risk.

Mayo Clinic

Imricor Medical Systems

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Imricor Medical Systems develops magnetic resonance imaging compatible electrophysiology tools for the treatment of cardiac arrhythmias.

Mayo Clinic

Venture Med Group

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VMG designs, develops which enable interventionalists to cost effectively treat peripheral artery diseases.

Mayo Clinic

Cryosa

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CryOSA is a medical device company developing novel treatments for obstructive sleep apnea.

Mayo Clinic

Reprise Biomedical

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Reprise Biomedical focuses on the development and commercialization of biological medical devices.

Mayo Clinic

FOXO Technologies

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FOXO Technologies is transforming the global longevity insurance industry with a next-generation underwriting protocol.

Mayo Clinic

Luminary Therapeutics

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Luminary Therapeutic is a cancer research center that develops pre-clinical stage cell therapy for cancer and autoimmune diseases.

Mayo Clinic

CardiaLen

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CardiaLen develops and commercializes pain-free cardioversion therapies for atrial fibrillation.

Mayo Clinic

MicroOptx

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MicroOptx is an early-stage medical device company that leverages academic bioengineering.

Mayo Clinic

Preceptis Medical

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Preceptis Medical develops surgical tools that allow ear tube procedures to be performed with less pain.

Mayo Clinic

Tendyne Holdings

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Tendyne is a medical device company developing a transcatheter aortic valve implantation system.

Mayo Clinic

Vergent Bioscience

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Vergent Bioscience is a biotech company leading the development of tumor-targeted molecular imaging molecules for cancer surgery.

Mayo Clinic

CoreBiome

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Provides fast, accurate genomic profiles of microbial communities to customers in pharmaceutical, agriculture, and academic research.

Mayo Clinic

JanOne

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JanOne is a pharmaceutical company focused on finding treatments for conditions that cause severe pain and bringing to market drugs.

Mayo Clinic

Vixar

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Vixar develops optical components and subassemblies for sensor applications in the biomedical, industrial, and automotive industries.

Mayo Clinic

Geneticure

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Geneticure is a personalized medicine company with patented tests that control chronic diseases faster than trial/error, with less cost

Mayo Clinic

AUM Cardiovascular

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AUM Cardiovascular is a medical device manufacturing company that specializes in the fields of biotechnology, medical, and healthcare.

Mayo Clinic

Canomiks

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Canomiks’ genomics, bioinformatics, and AI-based Product Superiority Platform helps companies create safe and efficacious products.

Mayo Clinic

SpineThera

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SpineThera develops novel, sustained-release, injectable drugs to treat pain.

Mayo Clinic

Veravas

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Veravas is a company that develops high value solutions for the accurate diagnosis of the world’s most devastating diseases.

Mayo Clinic

Aurora Pharmaceutical

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Aurora Pharmaceutical is a veterinary pharmaceutical company that develops and manufactures veterinary pharmaceutical products.

Mayo Clinic

Insitu Biologics

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InSitu Biologics is a developer of a drug delivery platform designed to focus on development of new and proprietary treatments.

Mayo Clinic

Segetis

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Segetis is transforming the chemical industry by offering unique material properties, cost effective economics.

Mayo Clinic

Augustine Temperature Management

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Augustine Temperature Management develops conductive fabric patient warming systems for surgical patients in the United States.

Mayo Clinic

Nirva Medical

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Nirva Medical is a medical device start up focusing on organ-specific therapy-delivery technology for various clinical applications.

Mayo Clinic

OX2 Therapeutics

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OX2 Therapeutics is a healthcare therapeutics company that focuses on treating brain tumors.

Mayo Clinic

Stratix Labs

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Stratix Labs develops and markets innovative microbiology products for research, development, and quality control applications.

Mayo Clinic

LEAH Labs

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LEAH Labs provides Car T cells for curing B-cell lymphoma cancer in dogs .

Mayo Clinic

RoverMed BioSciences

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RoverMed has developed precision targeted nanocapsule technology aimed at delivering life saving drugs to the most challenging disease sites

Mayo Clinic

Cardia

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Cardia is an innovative company engaged in developing, manufacturing and marketing transcatheter septal occluders.

Mayo Clinic

Phenomix Sciences

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Phenomix Sciences is a biotechnology company that specializes in biotech, life science, metabolomics, and genomics.

Mayo Clinic

CranioVation

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CranioVation is an innovative solution to treat aggressive brain tumors using light delivered via a minimally invasive device.

Mayo Clinic

B-MoGen Biotechnologies

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B-MoGen Biotechnologies is a genome engineering startup out of Minneapolis, MN.

Mayo Clinic

EmboMedics

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EmboMedics develops and commercializes resorbable and drug-loaded embolization devices for the treatment of multiple indications.

Mayo Clinic

Pelvital

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Pelvital is a privately held company that restores Pelvic Health and improve the lives of people.

Mayo Clinic

GRIP Molecular Technologies

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GRIP Molecular is a molecular detection device used at point-of-care to enable the rapid identification of chemical and biological threats.

Mayo Clinic

Protégé Biomedical

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Protégé Biomedical is a company with a unique new line of hemostatic products developed to stop bleeding in animals and humans*.

Mayo Clinic

CNS Therapeutics (Old)

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CNS Therapeutics develops pharmaceuticals for the treatment of neurological disorders and chronic pain.

Mayo Clinic

Delve Health

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Market place for clinical literature reviews and publications.

Mayo Clinic

Uromedica

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Uromedica is a medical device company developing an adjustable balloon device for stress urinary incontinence (SUI).

Mayo Clinic

Biomedix vascular solution

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Biomedix, a health care technology company, builds and supports community-based collaborative health care networks.

Mayo Clinic

SubioMed

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SubioMed specializes in the invention and development of suspension biomechanics technology addressing gait and balance.

Mayo Clinic

Imanis Life Sciences

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Imanis is a biotechnology company that specializes in oncolytic virotherapy and reporter gene imaging.

Mayo Clinic

Zurich Medical

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Zurich Medical develops proprietary medical devices.

Mayo Clinic

BRTI Life Sciences

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BRTI Life Sciences concentrates on cell research and therapeutics.

Mayo Clinic

Prism Clinical Research

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Prism Clinical Research is a research company offering medical research services.

Mayo Clinic

Mill Creek Life Sciences

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Mill Creek Life Sciences provides tools and technologies to support the development and application of cellular and biologic therapeutics.

Mayo Clinic

Tychon Bioscience

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Tychon Bioscience is a biotechnology company commercializing adaptive immunotherapy technology.

Mayo Clinic

GT Urological

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GT Urological, LLC develops, manufactures, distributes, and markets medical devices for the urinary incontinence market.

Mayo Clinic

Cambridge Technologies

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Cambridge Technologies is an independent owner-operated custom vaccine company working with veterinarians and livestock producers.

Mayo Clinic

Wound Care Technologies

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Wound Care Technologies, a medical technology company, develops and markets external tissue expansion devices for the wound care market.

Mayo Clinic

Shape Medical Systems

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Shape Medical Systems develops cardiopulmonary exercise testing technology to improve the early detection and treatment of heart failure.

Mayo Clinic

Medafor

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Medafor develops novel hemostatic technology and absorbable hemostats called MPH(R), which accelerates the normal blood clotting process.

Mayo Clinic

Hennepin Life Sciences

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Hennepin Life Sciences is a University of Minnesota spin-out developing treatments for women’s health conditions.

Mayo Clinic

Martell Diagnostic Laboratories

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Martell Diagnostic Laboratories is a Biotechnology company.

Mayo Clinic

Dgimed Ortho

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DGIMed Ortho is an early-stage orthopedic trauma company that develops an intramedullary nailing system and distal targeting device.

Mayo Clinic

CloSys

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CloSys develops hemostatic devices used for rapid vascular closure for anti-coagulated patients.

Mayo Clinic

InterValve

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InterValve develops medical devices and technology for the catheter-based treatment of calcified aortic valve stenosis.

Mayo Clinic

Circle Biologics

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Circle Biologics develops and markets biologic treatments and intra-operative biologic material management systems.

Mayo Clinic

Vertical Health Solutions

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Vertical Health Solutions develops MRI quality assurance software technologies to hospitals and imaging centers in the U.S.

Mayo Clinic

Prospex Medical

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Prospex Medical is a medical device incubator focused on innovating and incubating novel medical technologies.

Mayo Clinic

Bio-Techne

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Bio-Techne is a supplier of high quality and innovative tools for Life Science Research, Therapeutic Manufacturing and Clinical Diagnostics.

Mayo Clinic

Hypertension Diagnostics

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Hypertension Diagnostics designs and manufactures non-invasive medical devices that detect subtle changes in the elasticity of arteries.

Mayo Clinic

Way2B

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The Revolutionary New Way to Support YOUR Health

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