101 Best Massachusetts Pharmaceutical Companies and Startups

October 27, 2021
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This article showcases our top picks for the best Massachusetts based Pharmaceutical companies. These startups and companies are taking a variety of approaches to innovating the Pharmaceutical industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

  • Innovation
    • Innovative ideas
    • Innovative route to market
    • Innovative product
  • Growth
    • Exceptional growth
    • Exceptional growth strategy
  • Management
  • Societal impact

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Top Massachusetts Pharmaceutical Startups

Data sourced from Crunchbase and SemRush.

Pear Therapeutics

Pear Therapeutics

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Pear Therapeutics is a software-based digital therapeutics platform designed to treat disease and enhance the efficacy of pharmaceuticals.

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EQRx

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EQRx is a biotechnology company that focuses on re-engineering the process of drug discovery to make them affordable.

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Pyxis Oncology

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Pyxis Oncology is a developer of antibody therapeutics intended to promote the body’s immune response to cancer.

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Centessa Pharmaceuticals

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Centessa Pharmaceuticals is a next-generation biopharmaceutical company that aims to reshape the traditional drug development process.

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nference

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nference.inc, provides an AI based software platform that synthesizes siloed biomedical knowledge for insights and makes it computable.

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Moderna Therapeutics

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Moderna Therapeutics is a biotechnology company that specializes in drug discovery and drug development based on messenger RNA.

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Stealth BioTherapeutics

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Stealth BioTherapeutics is a clinical-stage biotechnology company focused on the discovery and commercialization of novel therapies.

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Exo Therapeutics

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Exo Therapeutics is a small molecule drug discovery and development company.

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Acceleron Pharma

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Acceleron is a biopharmaceutical company engaged in developing, manufacturing and commercializing novel biotherapeutics.

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ConcertAI

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ConcertAI is an AI-powered SaaS data company in healthcare that develops medical research tool in oncology.

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Axial Therapeutics

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Axial Therapeutics is a clinical stage biopharmaceutical company harnessing the gut-brain axis to develop novel Central Nervous System.

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TetraScience

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TetraScience is an R&D cloud data management company that empowers transformation in life sciences and drug discovery.

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Bluebird Bio

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Bluebird Bio offers products based on the transformative potential of gene therapy for patients with genetic and orphan diseases.

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Repligen

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Repligen is a biopharmaceutical company developing consumable products for the manufacture of biological drugs.

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Obsidian Therapeutics

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Obsidian Therapeutics is a developer of a next-generation cell and gene therapies created to extend adoptive immunotherapy.

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Charles River Laboratories International

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Charles River Laboratories International provides research models, and outsourced preclinical services for the accelerated R&D of drugs

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Quanterix

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Quanterix is a platform for single molecule analysis that supports clinical diagnostics, drug development, and life science researches.

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Stoke Therapeutics

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Stoke is developing antisense oligonucleotide medicines that target RNA splicing to increase gene expression for the treatment.

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Seven Bridges

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Seven Bridges is the leading biomedical data science company.

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XtalPi

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XtalPi is a biotech firm that uses artificial intelligence and computing to accelerate the development of new pharmaceutical drugs.

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Amylyx Pharmaceuticals

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Amylyx Pharmaceuticals specializes in providing solutions for Alzheimer’s and other diseases of the brain.

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PillPack

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PillPack is a full-service pharmacy that sorts medication by dose and offers door-to-door delivery.

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TScan Therapeutics

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TScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.

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Alnylam Pharmaceuticals

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Alnylam Pharmaceuticals is a biopharmaceutical company focused on the discovery, development and commercialization.

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Cerevel Therapeutics

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Cerevel Therapeutics is a biopharmaceutical company.

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Lyndra Therapeutics

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Lyndra Therapeutics is a novel technology platform reinventing medicine for a healthier world.

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4G Clinical

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4G Clinical provides software and services for clinical drug trials specifically in randomization and trial supply management (RTSM).

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TriNetX

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TriNetX is the global health research network that revolutionizes clinical research

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Dyne Therapeutics

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Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.

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Apellis Pharmaceuticals

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Apellis Pharmaceuticals focuses on developing novel therapeutics and drug delivery technologies to address chronic inflammatory diseases.

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Cellarity

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Cellarity’s platform digitizes the molecular information in cells to elucidate how they behave in health and disease.

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Rapid Micro Biosystems

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Rapid Micro Biosystems offers tools that detect microbial contamination in manufacturing pharmaceutical, biotechnology and other products.

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Rhythm Pharmaceuticals

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Rhythm is a biopharmaceutical company focused on developing and commercializing peptide therapeutics

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KSQ Therapeutics

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KSQ Therapeutics is using CRISPR technology within a powerful drug discovery engine to enable high-confidence drug development.

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Aura Biosciences

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Aura Biosciences is a biotechnology company that focuses on the development of drugs by using tumor targeted pseudovirions.

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Qstream

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Qstream is a microlearning platform that quantifiably improves job proficiency and changes behavior that results in teams who excel.

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Infinity Pharmaceuticals

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Infinity Pharmaceuticals engages in the discovery and development of medicines for the treatment of cancer and related conditions.

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Dicerna Pharmaceuticals

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Dicerna Pharmaceuticals is a biotechnology company involved in the discovery and development of innovative treatments.

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Adagio Therapeutics

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Adagio Therapeutics offers research and development of therapeutic pharmaceuticals related to COVID-19.

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Constellation Pharmaceuticals

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Constellation Pharmaceuticals develops drugs in the field of epigenetics focusing on selective regulators of its function.

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Rubius Therapeutics

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Rubius has developed the technology to grow, genetically engineer and mature long-circulating Red-Cell Therapeutics.

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Axcella

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Axcella is a biotechnology company providing therapeutics development solutions.

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Cyteir Therapeutics

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Cyteir is developing the next generation of synthetic lethal therapies to treat cancer.

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Ironwood Pharmaceuticals

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Ironwood Pharmaceuticals is an entrepreneurial pharmaceutical company, develops drugs for gastrointestinal and cardiovascular diseases.

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Fog Pharmaceuticals

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FogPharma creates a new class of medicines that target human disease drivers currently considered undruggable.

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Ultivue

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Ultivue is a biotechnology company that specializes in tissue imaging, diagnostics, and multiplexing.

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X4 Pharmaceuticals

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X4 Pharmaceuticals a clinical-stage oncology company developing best-in-class oral small molecule CXCR4 antagonists for the treatment.

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Akouos

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Akouos is a biotechnology company focusing on restoring and preserving hearing.

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Swoop

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Swoop is a provider of artificial intelligence and machine learning solutions to find, engage, and convert the ideal patient population.

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Selecta Biosciences

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Selecta Biosciences is a clinical-stage biotechnology company with an unrelenting commitment to overcoming immunogenicity.

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Orna Therapeutics

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Orna Therapeutics is a biotechnology company that specializes in fully engineered circular RNA (oRNA) therapeutics to treat various diseases

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ROME Therapeutics

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ROME Therapeutics is developing novel therapies for cancer and autoimmune diseases by harnessing the power of the repeatome.

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Affinivax

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Affinivax is a biopharmaceutical company developing vaccines used to enhance the depth of protection against infectious diseases.

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SmartLabs

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SmartLabs builds and operates enterprise-grade labs, including multi-use R&D labs, vivariums, process development, and manufacturing suites.

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Jounce Therapeutics

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Jounce Therapeutics is developing cancer immune-therapies to harness the immune system to attack cancerous cells and tumors.

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TCR2

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TCR2 is a discovery stage pharmaceutical company that developed a unique proprietary TRuC™ platform.

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Kala Pharmaceuticals

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Kala Pharmaceuticals develops novel treatments for diseases that affect mucosal tissues.

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Karyopharm Therapeutics

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Karyopharm Therapeutics is a clinical-stage pharmaceutical company developing drugs for the treatment of cancer and other major diseases.

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Syros Pharmaceuticals

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Syros Pharmaceuticals is a life sciences company that focuses on treating diseases by mapping gene regulatory circuits.

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Vor Biopharma

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Vor Biopharma is an immuno-oncology company that develops therapies for treating cancer.

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Verastem Oncology

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Verastem is a biopharmaceutical company that focuses on discovering and developing novel drugs that selectively target cancer stem cells.

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Anji Pharmaceuticals

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Anji Pharmaceuticals is focused on tackling high-value targets validated by human genetics.

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Radius Health

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Radius Health develops drug therapies for osteoporosis and women’s health.

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Arrakis Therapeutics

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Arrakis Therapeutics is a biopharmaceutical developing drugs for neurological disorders and other diseases.

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RxAdvance

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RxAdvance, a national full service PBM, leverages disruptive Collaborative PBM Cloud™ to manage standard & specialty drug benefits.

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FORMA Therapeutics

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FORMA Therapeutics is a biopharmaceutical company intended for the discovery, development and commercialization of transformative medicines.

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Cyclerion Therapeutics

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Cyclerion Therapeutics is a clinical-stage biopharmaceutical company.

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Reverie Labs

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Reverie Labs is a machine learning-driven pharma company.

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OncXerna Therapeutics

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OncXerna Therapeutics offers precision medicine using an innovative RNA-based biomarker platform.

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Keros Therapeutics

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Keros is a clinical-stage biopharmaceutical company focusing on the discovery, development, and commercialization of novel treatments.

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AVEO Oncology

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AVEO is a biopharmaceutical company that offers drug development strategies for targeted cancer therapeutics.

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Deciphera Pharmaceuticals

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Deciphera Pharmaceuticals focuses on improving kinase inhibitor treatments.

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Elicio Therapeutics

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Elicio Therapeutics develops an immuno-tumor vaccine to treat cancer.

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Q-State Biosciences

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Q-State has developed world-leading technologies and proprietary approaches for probing rare and genetic CNS conditions.

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Checkmate Pharmaceuticals

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Checkmate Pharma is a clinical stage biopharmaceutical company developing a new approach for cancer immunotherapy.

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Korro Bio

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Korro Bio provides an efficient and selective method for RNA editing, leveraging natural processes common to all multi-cellular organisms.

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Pieris Pharmaceuticals

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Pieris Pharmaceuticals is a clinical-stage biotechnology company applying its proprietary.

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Fresenius Medical Care North America

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Fresenius Medical Care North America provides healthcare services to people with renal and other chronic conditions.

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Syndax Pharmaceuticals

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Syndax Pharmaceuticals focuses on developing an HDAC inhibitor for solid tumors and hematological tumors.

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Clinical Research IO

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Clinical Research IO is a health tech company that offers paper-based clinical trials with software, eSource, CTMS, and eRegulatory.

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CardioFocus

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CardioFocus is a biotechnology company that focuses on the advancement of ablation treatments for cardiac disorders.

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Palleon Pharmaceuticals

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Palleon Pharmaceuticals is a developer of a biotechnology platform designed to offer glycoimmune checkpoint inhibitors to treat cancer.

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Pharmaron

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Pharmaron is a research and development service provider for the pharmaceutical industry.

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Bantam Pharmaceutical

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Bantam Pharmaceutical has deep experience in oncology drug discovery and development including R&D and partnering.

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Silicon Therapeutics

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Silicon Therapeutics is a fully integrated drug design, research, and development company.

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Rational Vaccines

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Rational Vaccines is a pre-clinical stage that develops live-attenuated herpes simplex virus vaccines.

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Santi Therapeutics

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Santi Therapeutics is a pharmaceutical company that focuses on the research and development of small molecule therapeutics.

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Immuneering

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Immuneering is a bioinformatics company that develops new medicines unlikely to be found by traditional drug discovery methods.

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Corbus Pharmaceuticals

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Corbus Pharmaceuticals is a clinical-stage pharmaceutical company focused on treating inflammatory and fibrotic diseases.

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TARIS Biomedical

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TARIS Biomedical is a pharmaceutical company developing therapies for genitourinary system issues.

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Entasis Therapeutics

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Entasis Therapeutics is developing a portfolio of innovative cures.

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Pulmatrix

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Pulmatrix develops inhaled therapies for the treatment, prevention and transmission of infectious and progressive respiratory diseases.

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Kernal Biologics

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Kernalbio creates mRNA therapies that instruct specific cells on how to make their own medicine.

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Neurogastrx

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A private biopharmaceutical company .

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Windgap Medical

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WindGap Medical is a biotech company that manufactures medical devices used to treat patients with severe allergies.

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Monocl

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Monocl empowers life science professionals with the complete global expert solution for impactful outreach and strategic engagement.

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Allena Pharmaceuticals

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Allena Pharmaceuticals develops and commercializes non-systemic protein therapeutics to treat metabolic and orphan diseases.

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Lyra Therapeutics

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Lyra Therapeutics is a clinical-stage company developing medicines to treat ear, nose, and throat diseases.

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Karuna Therapeutics

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Karuna Therapeutics is a Massachusetts-based developer of drugs for the treatment of schizophrenia.

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Azurity Pharmaceuticals

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Azurity Pharmaceuticals is a developer of drug products and technologies to address the needs of patients.

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HotSpot Therapeutics

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HotSpot Therapeutics is a developer of a therapy platform designed to discover medicines and provide proper treatment.

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