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85 Top San Francisco Cryptocurrency Companies and Startups of 2021

This article showcases our top picks for the best San Francisco based Cryptocurrency companies. These startups and companies are taking a variety of approaches to innovating the Cryptocurrency industry, but are all exceptional companies well worth a follow.

We tried to pick companies across the size spectrum from cutting edge startups to established brands.

We selected these startups and companies for exceptional performance in one of these categories:

Top San Francisco Cryptocurrency Startups

Data sourced from Crunchbase and SemRush.

Ripple

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Ripple provides one frictionless experience to send money globally using the power of blockchain.

Bitwise

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Bitwise is a crypto index fund manager for individuals, investment managers, and institutions navigating cryptocurrency.

Coinbase

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Coinbase is an online platform that allows merchants, consumers, and traders to transact with digital currency.

Uphold

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Uphold is a digital wallet and trading platform that enables cryptocurrencies and other assets affordable and accessible for everyone.

Solana

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Solana is a crypto startup that builds and develops crypto apps for decentralized apps and marketplaces.

FTX Exchange

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FTX Exchange is a cryptocurrency derivatives exchange company built by traders, for traders.

TRM Labs

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TRM Labs monitors digital asset transactions to protect financial institutions from risks like fraud and money laundering.

dYdX

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dYdX is a leading decentralized exchange offering Perpetual, Margin, & Spot trading, as well as borrow / lend pools on Ethereum.

Helium

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Helium is an Internet-of-Things developer platform for building the network and transferring IoT device data.

Stellar Development Foundation

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A non-profit organization that supports the development and growth of Stellar, a blockchain network that connects financial infrastructure.

Bitski

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Bitski allows creators, brands, and platforms to create, sell, and purchase NFTs.

Wyre

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Wyre develops a wide variety of payment APIs that offer a fast and cost-effective way of transferring money.

Chia Network

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Chia Network is building a blockchain platform based on Proofs of Space and Time.

CoinList

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CoinList provides a platform for digital asset companies to run their token sales.

Set Labs

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Set Labs is a crypto-financial platform that allows users to create baskets of cryptocurrency, NFTs, and on-chain securities.

Compound

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Compound is an open-source interest rate protocol that unlocks new financial applications.

TrustToken

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TrustToken is a platform to create asset-backed tokens that can be used for buying and selling around the world.

Hashflow

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Hashflow is a hybrid approach to decentralized finance (DeFi) trading.

Eco

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Eco provides a digital global cryptocurrency platform that can be used as a payment tool for daily-use transactions.

Harbor

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Harbor is helping to power the next big wave in capital markets โ€“ tokenized securities โ€“ by automating regulatory compliance.

O(1) Labs

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O(1) Labs is a software development company working on Mina Protocol, a tiny, portable blockchain.

0x

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0x is an open protocol that enables peer-to-peer trading of assets.

Aleo

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Aleo is building the worldโ€™s leading developer platform for enabling absolute privacy on blockchains.

MobileCoin

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MobileCoin is a cryptocurrency platform that develops P2P payment tokens and digital payment systems for mobile.

River Financial

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River Financial is a Bitcoin financial institution allowing long-term investors to buy, sell, and manage Bitcoin.

NuCypher

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NuCypher is a cryptography company that builds privacy-preserving infrastructure and protocols.

SKALE Labs

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SKALE Labs is a blockchain scalability platform that provides high speed consensus and empowers dApps to run smart contracts.

CoinTracker

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CoinTracker is a portfolio and tax manager for cryptocurrency.

Securitize

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Securitize enables digital securities, which are easier to own, simpler to manage, and faster to trade.

Kava Labs

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Kava Labs is a developer of Kava, is the most trusted DeFi platform by financial institutions

Fei Protocol

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Fei Protocol is a direct incentive stable coin which is undercollateralized and fully decentralized.

Digital Finance Group

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Diversified investment group that manages $1B in digital & blockchain assets across multiple funds, an incubator and global projects

Omniex

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Omniex develops software infrastructure that integrates front, middle, and back-office services to simplify access and remove fragmentation.

Opyn

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Opyn allows users to earn a premium or take views on assets by trading options on ETH and ERC20s.

Reflexer Labs

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Reflexer Labs is a new decentralized finance project aimed at softening volatility.

Coinbase Ventures

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Coinbase Ventures is an investment arm of Coinbase that aims to invest in early-stage cryptocurrency and blockchain startups.

CryptiSwap

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CryptiSwapยฉ is a Non-Custodial CryptoCurrency exchange/swap service | no registration | no holds | no third party

Iron Fish

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Iron Fish is a novel cryptocurrency focused on privacy and accessibility.

Rare Bits

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Rare Bits is a zero-fee peer-to-peer marketplace to buy, sell, and discover crypto goods.

Connext

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Connext is a crosschain liquidity network that enables fast, fully-noncustodial transfers between EVM-compatible chains and L2 systems.

Snowball Money

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Snowball Money operates as a crypto investment automation platform that provides access to professionally curated portfolios.

Saddle Finance

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Saddle Finance is an automated market maker (AMM) optimized for pegged value crypto assets.

BarnBridge

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Tokenized risk protocol

Mudrex

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Smart crypto investment on autopilot

Apto Payments

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Apto Payments is a card issuance platform that helps companies issue new kinds of cards in new ways.

Zerion

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Zerion is an all-in-one interface that allows technical and non-technical users to acquire, track and manage DeFi assets.

Agoric

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Agoric provides a framework for programming smart contracts securely and with ease, beyond anything available today.

Sperax

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Sperax builds the most secure and scalable infrastructure for decentralized financial services.

Polkaswitch

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A decentralized multi-chain liquidity protocol on Polkadot, Ethereum, and top layer 1 & 2 blockchains.

Coinbase CBT

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Coinbase CBT is a IEO fund raising project of Coinbase that aims to connect with millions of crypto investors around the world.

Async Art

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Collect and Experience Rare Programmable Art.

AnchorUSD

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AnchorUSD offers stable currency anchored 1-for-1 to the US dollar (USDX).

Commonwealth Labs

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Commonwealth Labs is a governance startup offering a new twist on token airdrops.

Slingshot Finance

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Next-gen decentralized trading platform

CASPIAN

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CASPIAN is a full stack crypto asset management solution.

Multis

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Multis provides financial services for companies holding euros, dollars, and cryptocurrencies.

Anchorage

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Anchorage is a digital asset platform offering custody, trading, and financing services, as well as staking and governance.

Provenance Blockchain

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Provenance Blockchain combines the distributed, trustless, and immutable characteristics of blockchain.

Risk Harbor

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The only objective risk management marketplace for decentralized finance (DeFi).

Linen App

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New experience that allows our members to earn high yield on their cash.

Round Finance Inc.

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Building an aggregator of digital assets and experiences

BLADE

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BLADE is a cryptocurrency derivatives exchange

Idex.io

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Idex.io is a decentralized cryptocurrency exchange.

Purse

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Purse provides real incentive to use Bitcoin to the largest selection at the lowest price points.

SureRemit

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SureRemit is an ecosystem for global non-cash remittances.

Bitnet Technologies

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Bitnet Technologies is a digital commerce platform that helps enterprise scale merchants to accept bitcoin payments.

gumi Cryptos Capital (gCC)

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gumi Cryptos Capital is a blockchain and cryptographic asset venture fund

Yours

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Yours is a blockchain-based social network where users can earn bitcoin.

DCEX

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DCEX is a US based digital currency exchange with OTC desk, digital dollar DCEX$ and a Digital currency news site

ZeFi

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ZeFi develops a neobanking platform that provides a permission less financial ecosystem without a central authority.

TokenInsight

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TokenInsight is dedicated towards providing accurate data and ratings for cryptocurrency companies through transparency.

Layer1

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Layer1 builds turnkey Bitcoin mining data centers that boost the profitability of energy assets.

Picks & Shovels

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The Picks & Shovels Co. crafting tools for investors and traders of digital currencies and crypto assets.

Beanstalk Network

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Beanstalk Network is a research and development company for privacy preserving financial transactions.

MetaMask

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MetaMask is a crypto wallet and gateway to blockchain apps.

Apifiny

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A global digital asset trading network unifying fragmented markets, providing superior liquidity and trade execution for professionals.

StudentCoin

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StudentCoin is a universal cryptocurrency for students where the users owns 100% of the company.

Hexel

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Hexel is a startup that wants to make it easy for anyone to use Ethereum-based tokens to engage their hyperlocal community.

Satochi

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Fintech, Investing, Cryptocurrency, Consumer

LoopX

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LoopX is helps to find the Best Worldwide Online Casino and provides information.

Bitbutter

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Crypto-asset account aggregation API for fintechs and financial institutions.

Volt Capital

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Volt Capital is a research and community driven crypto fund.

ChangeTip

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ChangeTip facilitates global micropayments across every social media or digital platform.

Dapps

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Enterprise Blockchain Computing (EBC)

Portal

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Portal is a financial services company that trades crypto without putting coins at risk.

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